دنیای نانو

دنیای نانو

نانولوله‎های کربنی بارگذاری شده با دارو‎های ضدسرطانی: یک بستر برای درمان هدفمند سرطان با مدل‎های مختلف

نوع مقاله : مقاله پژوهشی

نویسنده
گروه شیمی، دانشکده علوم، دانشگاه گلستان، گرگان، ایران
چکیده
نانولوله‎های کربنی (CNTs) لوله‎هایی از کربن گرافیتی در مقیاس مولکولی می‎باشد. آن‎ها جزو سفت‎ترین و قوی‎ترین الیاف شناخته شده هستند، و دارای خواص الکترونیکی قابل توجه و دیگر خصوصیات منحصر به فرد می‎باشد. این خصوصیات منحصر به فرد این نانولوله‌ها که ترکیبی از خواص مغناطیسی، نوری، الکتریکی و شیمیایی است، آن‎ها را برای توسعه یک دسته جدید از داروها و درمان برپایه نانولوله‎های کربنی بسیار قدرتمند و مناسب ساخته است. در مقاله پیش رو خلاصه‎ای از خواص نانولوله‎های کربنی و اینکه چگونه آن‎ها می‎توانند برای این اهداف به‎کارگرفته شوند؛ به همراه یک مرور کلی از وضعیت فعلی در این زمینه و چشم‎انداز آینده ارائه خواهد شد.
کلیدواژه‌ها

موضوعات


عنوان مقاله English

Carbon nanotubes loaded with anticancer drugs: a platform for targeted cancer therapy with different models

نویسنده English

Milad Kazemnejadi
Chemistry Department,, Faculty of Sciences, Golestan University, Gorgan, Iran
چکیده English

Carbon nanotubes (CNTs) are tubes of graphitic carbon on a molecular scale. They are among the stiffest and strongest fibers known, and have remarkable electronic properties and other unique properties. These unique properties of the nanotubes, which are a combination of magnetic, optical, electrical and chemical properties, have made them very powerful and suitable for the development of a new category of drugs and treatments based on carbon nanotubes. In the following article, a summary of the properties of carbon nanotubes and how they can be used for these purposes; Along with an overview of the current situation in this field and the future perspective will be presented.
Carbon nanotubes (CNTs) are molecular-scale tubes of graphitic carbon with remarkable electronic properties and other unique properties. Carbon nanotubes as building blocks for protein and DNA biosensors, ion channel blockers (a type of drug that binds to the cavity of a specific type of ion channel and blocks the flow of ions into it and causes the concentration gradient of nerve cell membrane to change and therefore changes in nerve transmission), biological separators and biocatalysts have been used

کلیدواژه‌ها English

Carbon nanotubes
drug delivery
medicine
targeted
  • Prajapati SK, Malaiya A, Kesharwani P, Soni D, Jain A. Biomedical applications and toxicities of carbon nanotubes. Drug and chemical toxicology. 2022 Jan 2;45(1):435-50. https://doi.org/10.1080/01480545.2019.1709492
  • Thakur A, Bharti R, Sharma R. Carbon nanotubes: Types, synthesis, cytotoxicity and applications in biomedical. Materials Today: Proceedings. 2022 Jan 1;50:2256-68. https://doi.org/10.1016/j.matpr.2021.10.002
  • Dubey R, Dutta D, Sarkar A, Chattopadhyay P. Functionalized carbon nanotubes: Synthesis, properties and applications in water purification, drug delivery, and material and biomedical sciences. Nanoscale Advances. 2021;3(20):5722-44. https://doi.org/1039/D1NA00293G
  • Anzar N, Hasan R, Tyagi M, Yadav N, Narang J. Carbon nanotube-A review on Synthesis, Properties and plethora of applications in the field of biomedical science. Sensors International. 2020 Jan 1;1:100003. https://doi.org/10.1016/j.sintl.2020.100003
  • Tans SJ, Verschueren AR, Dekker C. Room-temperature transistor based on a single carbon nanotube. Nature. 1998 May 7;393(6680):49-52. https://doi.org/10.1038/29954
  • Zhang X, Lu W, Zhou G, Li Q. Understanding the mechanical and conductive properties of carbon nanotube fibers for smart electronics. Advanced Materials. 2020 Feb;32(5):1902028. https://doi.org/10.1002/adma.201902028
  • Rathinavel S, Priyadharshini K, Panda D. A review on carbon nanotube: An overview of synthesis, properties, functionalization, characterization, and the application. Materials Science and Engineering: B. 2021 Jun 1;268:115095. https://doi.org/10.1016/j.mseb.2021.115095
  • Chen RJ, Bangsaruntip S, Drouvalakis KA, Wong Shi Kam N, Shim M, Li Y, Kim W, Utz PJ, Dai H. Noncovalent functionalization of carbon nanotubes for highly specific electronic biosensors. Proceedings of the National Academy of Sciences. 2003 Apr 29;100(9):4984-9. https://doi.org/10.1073/pnas.0837064100
  • Besteman K, Lee JO, Wiertz FG, Heering HA, Dekker C. Enzyme-coated carbon nanotubes as single-molecule biosensors. Nano letters. 2003 Jun 11;3(6):727-30. https://doi.org/10.1021/nl034139u
  • Bradley K, Briman M, Star A, Grüner G. Charge transfer from adsorbed proteins. Nano Letters. 2004 Feb 11;4(2):253-6. https://doi.org/10.1021/nl0349855
  • Forzani ES, Li X, Zhang P, Tao N, Zhang R, Amlani I, Tsui R, Nagahara LA. Tuning the chemical selectivity of SWNT‐FETs for detection of heavy‐metal ions. Small. 2006 Nov;2(11):1283-91. https://doi.org/10.1002/smll.200600185
  • Star A, Gabriel JC, Bradley K, Grüner G. Electronic detection of specific protein binding using nanotube FET devices. Nano letters. 2003 Apr 9;3(4):459-63. https://doi.org/10.1021/nl0340172
  • Patolsky F, Weizmann Y, Willner I. Long‐range electrical contacting of redox enzymes by SWCNT connectors. Angewandte Chemie. 2004 Apr 13;116(16):2165-9. https://doi.org/10.1002/ange.200353275
  • Yu X, Munge B, Patel V, Jensen G, Bhirde A, Gong JD, Kim SN, Gillespie J, Gutkind JS, Papadimitrakopoulos F, Rusling JF. Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers. Journal of the American Chemical Society. 2006 Aug 30;128(34):11199-205. https://doi.org/10.1021/ja062117e
  • Hendler-Neumark A, Wulf V, Bisker G. Single-Walled Carbon Nanotube Sensor Selection for the Detection of MicroRNA Biomarkers for Acute Myocardial Infarction as a Case Study. ACS sensors. 2023 Sep 13;8(10):3713-22. https://doi.org/10.1021/acssensors.3c00633
  • Li J, Ng HT, Cassell A, Fan W, Chen H, Ye Q, Koehne J, Han J, Meyyappan M. Carbon nanotube nanoelectrode array for ultrasensitive DNA detection. Nano letters. 2003 May 14;3(5):597-602. https://doi.org/10.1021/nl0340677
  • Cai D, Mataraza JM, Qin ZH, Huang Z, Huang J, Chiles TC, Carnahan D, Kempa K, Ren Z. Highly efficient molecular delivery into mammalian cells using carbon nanotube spearing. Nature Methods. 2005 Jun;2(6):449-54. https://doi.org/10.1038/nmeth761
  • Robinson DA. The electrical properties of metal microelectrodes. Proceedings of the IEEE. 1968 Jun;56(6):1065-71. https://doi.org/1109/PROC.1968.6458
  • Shein M, Greenbaum A, Gabay T, Sorkin R, David-Pur M, Ben-Jacob E, Hanein Y. Engineered neuronal circuits shaped and interfaced with carbon nanotube microelectrode arrays. Biomedical microdevices. 2009 Apr;11:495-501. https://doi.org/10.1007/s10544-008-9255-7
  • Rinzler AG, Hafner JH, Nikolaev P, Nordlander P, Colbert DT, Smalley RE, Lou L, Kim SG, Tománek D. Unraveling nanotubes: field emission from an atomic wire. Science. 1995 Sep 15;269(5230):1550-3. https://doi.org/1126/science.269.5230.1550
  • Cherukuri P, Gannon CJ, Leeuw TK, Schmidt HK, Smalley RE, Curley SA, Weisman RB. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proceedings of the National Academy of Sciences. 2006 Dec 12;103(50):18882-6. https://doi.org/10.1073/pnas.0609265103
  • Keefer EW, Botterman BR, Romero MI, Rossi AF, Gross GW. Carbon nanotube coating improves neuronal recordings. Nature nanotechnology. 2008 Jul;3(7):434-9. https://doi.org/10.1038/nnano.2008.174
  • Yantzi JD, Yeow JT. Carbon nanotube enhanced pulsed electric field electroporation for biomedical applications. InIEEE International Conference Mechatronics and Automation, 2005 2005 Jul 29 (Vol. 4, pp. 1872-1877). IEEE. https://doi.org/1109/ICMA.2005.1626847
  • Rojas-Chapana JA, Correa-Duarte MA, Ren Z, Kempa K, Giersig M. Enhanced introduction of gold nanoparticles into vital acidothiobacillus ferrooxidans by carbon nanotube-based microwave electroporation. Nano Letters. 2004 May 12;4(5):985-8. https://doi.org/10.1021/nl049699n
  • Cai D, Blair D, Dufort FJ, Gumina MR, Huang Z, Hong G, Wagner D, Canahan D, Kempa K, Ren ZF, Chiles TC. Interaction between carbon nanotubes and mammalian cells: characterization by flow cytometry and application. Nanotechnology. 2008 Jul 15;19(34):345102. https://doi.org/10.1088/0957-4484/19/34/345102
  • Raffa V, Ciofani G, Vittorio O, Pensabene V, Cuschieri A. Carbon nanotube-enhanced cell electropermeabilisation. Bioelectrochemistry. 2010 Aug 1;79(1):136-41. https://doi.org/10.1016/j.bioelechem.2009.10.006
  • Haddon RC. Magnetism of the carbon allotropes. Nature. 1995 Nov 16;378(6554):249-55. https://doi.org/10.1038/378249a0
  • Al-Kindi US, Al-Harthi SH, Myint MT, Kyaw HH, Widatallah HM, Elzain ME. The morphology and magnetic properties of iron nanoclusters decorated multiwall carbon nanotubes. Materials Research Bulletin. 2023 Feb 1;158:112061. https://doi.org/10.1016/j.materresbull.2022.112061
  • Pensabene V, Vittorio O, Raffa V, Ziaei A, Menciassi A, Dario P. Neuroblastoma cells displacement by magnetic carbon nanotubes. IEEE Transactions on NanoBioscience. 2008 Jun 6;7(2):105-10. https://doi.org/10.1016/1109/TNB.2008.2000749
  • Al Faraj A, Cieslar K, Lacroix G, Gaillard S, Canet-Soulas E, Crémillieux Y. In vivo imaging of carbon nanotube biodistribution using magnetic resonance imaging. Nano Letters. 2009 Mar 11;9(3):1023-7. https://doi.org/10.1021/nl8032608
  • Cherukuri P, Gannon CJ, Leeuw TK, Schmidt HK, Smalley RE, Curley SA, Weisman RB. Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence. Proceedings of the National Academy of Sciences. 2006 Dec 12;103(50):18882-6. https://doi.org/10.1073/pnas.0609265103
  • Aslam A, Aslam J, Parray HA, Hussain CM. Functionalization Carbon Nanotubes Innovate on Medical Technology. Functionalized Carbon Nanotubes for Biomedical Applications. 2023 Mar 7:75-94. https://doi.org/10.1002/9781119905080.ch4
  • Kam NW, O'Connell M, Wisdom JA, Dai H. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proceedings of the National Academy of Sciences. 2005 Aug 16;102(33):11600-5. https://doi.org/10.1073/pnas.0502680102
  • Zhou F, Xing D, Ou Z, Wu B, Resasco DE, Chen WR. Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes. Journal of biomedical optics. 2009 Mar 4;14(2):021009-. https://doi.org/10.1117/1.3078803
  • Wang, K. Kempa, B. Kimball, J.B. Carlson, G. Benham, W.Z. Li, T. Kempa, J. Rybczynski, A. Herczynski, Z.F. Ren, Applied physics letters, 85, 2607-2609, (2004).
  • Xiong, X. Kou, X. Zuo, G. Huang, L. Huang, P. Huang, Z. Kang, L. Xu, Z. Zou, Y. Zhao, ACS Applied Nano Materials, 6, 15764-15773, (2023). Xiong X, Kou X, Zuo X, Huang G, Huang L, Huang P, Kang Z, Xu L, Zou Z, Zhao Y. Sea Urchin-like SnS/Nitrogen-Doped Carbon Nanotube Dielectric Composites for Tunable Electromagnetic Response. ACS Applied Nano Materials. 2023 Aug 23;6(17):15764-73. https://doi.org/10.1021/acsanm.3c02646
  • Ban Q, Li Y, Li L, Qin Y, Zheng Y, Liu H, Kong J. Amorphous carbon engineering of hierarchical carbonaceous nanocomposites toward boosted dielectric polarization for electromagnetic wave absorption. Carbon. 2023 Jan 5;201:1011-24. https://doi.org/10.1016/j.carbon.2022.10.017

Wang B, Xu Z, Wu H, Huang F, Liu F, Li S, Zhang H. Architecture-inspired N-doped carbon nanotube bridging well-arranged MXene nanosheets toward efficient electromagnetic wave absorption. Composites Part B: Engineering. 2023 May 15;257:110669. https://doi.org/10.1016/j.compositesb.2023.110669

دوره 20، شماره 74
بهار 1403
صفحه 66-51

  • تاریخ دریافت 15 بهمن 1402
  • تاریخ پذیرش 25 اردیبهشت 1403