دنیای نانو

دنیای نانو

آنالیز اندازه ذرات و بار سطحی نانو سیستم های دارویی بوسیله پراکنش دینامیکی در درمان سرطان

نوع مقاله : مقاله پژوهشی

نویسندگان
1 دانشکده شیمی، دانشگاه صنعتی امیرکبیر ، تهران، ایران
2 پژوهشگاه پلیمر و پتروشیمی، تهران، ایران
چکیده
استفاده از نانوذرات به عنوان حامل دارو نیز به دلیل قابلیت حمل دارو به قسمت‌های مختلف بدن در زمان مناسب، بسیار مهم می باشد. استفاده از سیستم‌های دارورسانی بر پایه نانوذرات بارگذاری شده با عوامل ضد سرطان، روشی موثر برای هدفگذاری سلول‌های سرطانی است. این سیستم‌ها با قابلیت نفوذ بهتر در داخل سلول‌ها، دارو را به صورت هدفمند در سلول‌ها ترکیب می‌کنند. همچنین، به دلیل افزایش نفوذپذیری (EPR)، امکان تجمع بهتر داروها در محل تومور فراهم می‌شود. اندازه ذرات یکی از عوامل مهم و تأثیرگذار در نانوحامل‌های داروی ضد سرطان است. محدوده پتانسیل زتا بین 30- تا 30+ میلی ولت برای طراحی نانو حامل بسیار مناسب است زیرا باعث پایداری نانو حامل در جریان خون و همچین ماندگاری زیاد در جریان خون می شود. در بیشتر تحقیقات اندازه ذرات مناسب برای رهایش هدفمند نانو حامل های دارویی را، مقدار کمتر از 300 یا 200 نانومتر گزارش کرده اند. این مقدار مناسب برای کاربرد رهایش دارو برای انتشار در بین بافت ها می باشد و باعث ایجاد اثر افزایش نفوذپذیری می شود. این مطالعه برای اولین بار به بررسی و تحلیل اندازه ذرات به‌دست‌آمده از طریق آزمون پراکنش نوری دینامیکی و ارزیابی مقدار پتانسیل بارسطحی سطحی در بهبود رهایش داروهای ضد سرطان می‌پردازد.
کلیدواژه‌ها

موضوعات


عنوان مقاله English

Analysis of particle size and surface charge of pharmaceutical nanosystems by dynamic scattering in cancer treatment

نویسندگان English

MohammadHossein Karami 1
Majid Abdouss 1
Mandana Karami 2
1 Department of Chemistry, Amirkabir University of Technology, Tehran P.O. Box: 15875-4413
2 , Polymer and Petrochemical Research Institute, Tehran, Iran, PO Box: 14975/112
چکیده English

The utilization of nanoparticles as drug carriers is of utmost importance due to their ability to effectively transport drugs to specific areas of the body at the appropriate time. Incorporating anticancer agents into nanoparticle-based drug delivery systems has emerged as a highly efficient approach for targeting cancer cells. These systems possess the capability to penetrate cells more effectively, enabling the precise combination of drugs within the cells. Moreover, they take advantage of the enhanced permeability and retention (EPR) effect, allowing for better accumulation of drugs at tumor sites. Particle size is a critical factor influencing the efficacy of anticancer nanocarriers. The zeta potential range of -30 to +30 millivolts is particularly favorable for designing nanocarriers, as it ensures their stability in the bloodstream and prolonged circulation. Many studies have indicated that the optimal particle size for targeted drug release falls below 300 or 200 nanometers. This size range facilitates efficient drug diffusion among tissues and enhances permeability. This study, for the first time, focuses on analyzing particle size obtained through dynamic light scattering and evaluating the surface charge potential to enhance the release of anticancer drugs.

کلیدواژه‌ها English

Nanocarriers
Dynamic light scattering
Surface Charge
Zeta Potential
Dispersity Index
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دوره 20، شماره 74
بهار 1403
صفحه 14-1

  • تاریخ دریافت 20 شهریور 1402
  • تاریخ بازنگری 29 شهریور 1402
  • تاریخ پذیرش 04 مهر 1402