The efficiency of nanocavities in the uptake and release of diclofenac sodium (DS) from aqueous solutions was investigated. Silica nanocavity MCM-41 was synthesized and then, to provide an accessible porous network, surfactants were removed from the channel and then MCM-41(APTES) was modified and synthesized using 3-aminopropyltriethoxysilane (APTES). X-ray diffraction and FTIR techniques were used to investigate and identify the structure of both synthesized samples. The loading and release of diclofenac sodium drug on mesoporous materials was carried out. Various factors were evaluated for optimal absorption of diclofenac sodium on the surface of the support. Nitrogen adsorption/desorption of MCM-41 and its modified sample was investigated. The specific surface area and volume of the modified sample are reduced compared to the MCM-41 sample. The ultraviolet-visible (UV-Vis) spectrometer measurement showed that the drug loading in the amine-modified mesoporous materials is higher compared to MCM-41. The effect of parameters such as pH, carrier weight, drug loading time and other factors on drug loading and release on MCM-41 and MCM-41(APTES) carriers was investigated. With increasing ultrasonic irradiation time, the amount of drug loading decreased to some extent and remained constant after 10 minutes. In the acidic medium, the N-H group of 3-aminopropyltriethoxysilane is protonated. The protonation of the amine group causes a chemical interaction and thus the amount of drug release decreases. At higher pH, the repulsive force between the amine group and the carboxylate group increases the drug release.