دنیای نانو

دنیای نانو

تهیه و مشخصه یابی کامپوزیت هیدروژل CoFe2O4-پلی‌اکریلیک اسید پیوندی با صمغ گوار

نوع مقاله : مقاله پژوهشی

نویسندگان
1 محقق پسا دکتری، گروه مهندسی پلیمر، دانشگاه حکیم سبزواری، سبزوار، ایران.
2 استادیار گروه مهندسی پلیمر، دانشگاه حکیم سبزواری، سبزوار، ایران
3 استاد، آزمایشگاه تحقیقاتی کاتالیست‌ها و سنتزهای آلی، دانشکده شیمی، دانشگاه علم و صنعت ایران، تهران، ایران.
4 دانشجو دکترا، آزمایشگاه تحقیقاتی کاتالیست‌ها و سنتزهای آلی، دانشکده شیمی، دانشگاه علم و صنعت ایران، تهران، ایران.
چکیده
هیدروژل‌ها به دلیل ویژگی‌های منحصر به فردی مانند زیست‌سازگاری، زیست تخریب پذیری و قابلیت جذب آب، به‌عنوان بسترهای ایده‌آل در کاربردهای زیست پزشکی و دارورسانی مطرح هستند. پلیمرهای طبیعی به ویژه صمغ ها به دلیل زیست‌سازگاری، آبدوستی و توانایی اصلاح با تغییرات شیمیایی، برای ساخت هیدروژل‌های پیشرفته مناسب هستند. در این تحقیق، یک کامپوزیت جدید با ساختارGuar gum-grafted-poly(acrylic acid)/cobalt ferrite(GG-grafted-PAA/CoFe2O4) با هدف بهبود ویژگی‌های عملکردی و ارتقاء کاربردهای زیست پزشکی تهیه شد. کامپوزیت از طریق ‌پلیمریزاسیون پیوندی اکریلیک اسید (AA) بر روی صمغ گوار (GG) با استفاده از آمونیوم پر سولفات (APS) به‌عنوان آغازگر تهیه گردید. ذرات مغناطیسی CoFe2O4که از پیش با استفاده از روش هم رسوبی تهیه شدند در حین تکمیل فرآیند پلیمریزاسیون به محیط واکنش اضافه و در بستر هیدروژل تعبیه شدند و در پایان با اضافه شدن مخلوط واکنش به محلول بوراکس به عنوان عامل اتصال عرضی دهنده غیرسمی و زیست سازگار، شبکه سه بعدی هیدروژل تشکیل شد. برای شناسایی خواص شیمیایی و مورفولوژیکی، مقاومت حرارتی و ویژگی‌های مغناطیسی ، از آنالیزهای مختلفی شامل طیف‌سنجی تبدیل فوریه مادون قرمز (FTIR) ، آزمون تفرق پرتو ایکس (EDX)، آنالیز ترموگراویمتریک (TGA) ، آنالیز پراش اشعه ایکس (XRD) و میکروسکوپ الکترونی روبشی نشر میدانی (FESEM) استفاده شد. نتایج نشان داد که کامپوزیت رفتار فرومغناطیسی دارد و بر اساس نمودارهای هیستریس مغناطیسی، اشباع مغناطیسی (Ms) برابر emu/g 22/3 را نشان می‌دهد. آنالیز TGA نشان داد که اصلاح صمغ گوار و ایجاد کامپوزیت منجر به افزایش قابل توجه مقاومت حرارتی شد بطوریکه وزن باقی مانده آن در دمای°C 800، 60/72 درصد بود.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

Preparation and characterization of CoFe₂O₄-Poly(acrylic acid) Grafted Guar Gum hydrogel composite

نویسندگان English

Fereshte Hassanzadeh-Afruzi 1
Rasoul Esmaeely-Neisiany 2
aki maleki 3
mohammad mehdi salehi 4
1 Postdoctoral Researcher, Department of Polymer Engineering, Hakim Sabzevari University, Sabzevar, Iran.
2 Assistant Professor, Department of Polymer Engineering, Hakim Sabzevari University, Sabzevar, Iran
3 Professor, Catalysts and Organic Syntheses Research Laboratory, Faculty of Chemistry, Iran University of Science and Technology, Tehran, Iran.
4 Ph.D. Candidate, Catalysts and Organic Syntheses Research Laboratory, Faculty of Chemistry, Iran University of Science and Technology, Tehran, Iran.
چکیده English

Hydrogels are considered ideal matrices for biomedical and drug delivery applications due to their unique properties such as biocompatibility, biodegradability, and water absorption capacity. Natural polymers, especially gums, are particularly suitable for the fabrication of advanced hydrogels owing to their biocompatibility, hydrophilicity, and ability to be modified through chemical alterations. In this study, a novel composite with the structure Guar gum-grafted-poly(acrylic acid)/cobalt ferrite (GG-grafted-PAA/CoFe₂O₄) was synthesized to enhance functional properties and broaden biomedical applications. The composite was prepared through the graft polymerization of acrylic acid (AA) onto guar gum (GG) using ammonium persulfate (APS) as an initiator. Pre-synthesized cobalt ferrite (CoFe₂O₄) magnetic particles, obtained via the co-precipitation method, were incorporated into the hydrogel matrix during the polymerization process. A three-dimensional hydrogel network was formed by adding the reaction mixture to a borax solution, serving as a non-toxic and biocompatible crosslinking agent. The chemical properties, morphology, thermal stability, and magnetic characteristics of the composite were characterized using various analytical techniques, including Fourier-transform infrared spectroscopy (FTIR), energy-dispersive X-ray spectroscopy (EDX), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and field-emission scanning electron microscopy (FESEM). The results revealed that the composite exhibited ferromagnetic behavior, with a saturation magnetization (Ms) of 3.22 emu/g, as determined from magnetic hysteresis curves. TGA analysis indicated that the modification of guar gum and the formation of the composite significantly improved thermal resistance, with a residue weight of 72.6 % at 800°C.

کلیدواژه‌ها English

Natural Polymer
Guar Gum
Cobalt Ferrite
Hydrogel Composite
Graft Polymerization
[1] Shi, Z. et al., Electroconductive natural polymer-based hydrogels, Biomaterials at https://doi.org/10.1016/j.biomaterials.2016.09.020 2016.
[2] George, S. & Abraham, T. E., pH sensitive alginate-guar gum hydrogel for the controlled delivery of protein drugs, Int. J. Pharm. 2007 doi:10.1016/j.ijpharm.2006.11.009.
[3] Zhao, L. et al., Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications, Pharmaceutics at https://doi.org/10.3390/pharmaceutics15102514 2023.
[4] Verma, D. & Sharma, S. K., Recent advances in guar gum based drug delivery systems and their administrative routes, Int. J. Biol. Macromol. 2021 doi:10.1016/j.ijbiomac.2021.03.087.
[5] Palem, R. R., Shimoga, G., Rao, K. S. V. K., Lee, S. H. & Kang, T. J., Guar gum graft polymer-based silver nanocomposite hydrogels: synthesis, characterization and its biomedical applications, J. Polym. Res. 2020 doi:10.1007/s10965-020-2026-8.
[6] Singh, B., Sharma, S. & Dhiman, A., Acacia gum polysaccharide based hydrogel wound dressings: Synthesis, characterization, drug delivery and biomedical properties, Carbohydr. Polym. 2017 doi:10.1016/j.carbpol.2017.02.039.
[7] Pacelli, S. et al., Gellan gum methacrylate and laponite as an innovative nanocomposite hydrogel for biomedical applications, Eur. Polym. J. 2016 doi:10.1016/j.eurpolymj.2016.02.007.
[8] Mehdi Salehi, M. et al., Highly efficient remediation of chlorpyrifos and malachite green by an SBA-15 incorporated guar gum-grafted-poly (acrylic acid)/cobalt ferrite matrix for water purification, Arab. J. Chem. 2024 doi:10.1016/j.arabjc.2024.105751.
[9] Sharahi, M., Bahrami, S. H. & Karimi, A., A comprehensive review on guar gum and its modified biopolymers: Their potential applications in tissue engineering, Carbohydr. Polym., 347, 122739 2025.
[10] Mandal, S., Hwang, S. & Shi, S. Q., Guar gum, a low-cost sustainable biopolymer, for wastewater treatment: A review, Int. J. Biol. Macromol. at https://doi.org/10.1016/j.ijbiomac.2022.12.039 2023.
[11] Prabaharan, M., Prospective of guar gum and its derivatives as controlled drug delivery systems, Int. J. Biol. Macromol. at https://doi.org/10.1016/j.ijbiomac.2011.04.022 2011.
[12] Sudha, P. N., Pavithra, S., Murali, V. P., Alaswad, S. O. & Arunachalam, P., Advances in guar gum-based materials in biomedical applications with special reference to tissue engineering applications, Natural Biopolymers in Drug Delivery and Tissue Engineering, 2023. doi:10.1016/B978-0-323-98827-8.00019-9.
[13] Sharma, G. et al., Guar gum and its composites as potential materials for diverse applications: A review, Carbohydr. Polym. at https://doi.org/10.1016/j.carbpol.2018.07.053 2018.
[14] Ghauri, Z. H. et al., Development and evaluation of pH-sensitive biodegradable ternary blended hydrogel films (chitosan/guar gum/PVP) for drug delivery application, Sci. Rep. 2021 doi:10.1038/s41598-021-00452-x.
[15] Palem, R. R., Madhusudana Rao, K. & Kang, T. J., Self-healable and dual-functional guar gum-grafted-polyacrylamidoglycolic acid-based hydrogels with nano-silver for wound dressings, Carbohydr. Polym. 2019 doi:10.1016/j.carbpol.2019.115074.
[16] Mukherjee, B. et al., Guar gum-based nanomaterials in drug delivery and biomedical applications, Biopolymer-Based Nanomaterials in Drug Delivery and Biomedical Applications, 2021. doi:10.1016/B978-0-12-820874-8.00016-6.
[17] Murali, R., Vidhya, P. & Thanikaivelan, P., Thermoresponsive magnetic nanoparticle - Aminated guar gum hydrogel system for sustained release of doxorubicin hydrochloride, Carbohydr. Polym. 2014 doi:10.1016/j.carbpol.2014.04.076.
[18] Shahid, M. et al., Graft polymerization of guar gum with acryl amide irradiated by microwaves for colonic drug delivery, Int. J. Biol. Macromol. 2013 doi:10.1016/j.ijbiomac.2013.08.018.
[19] Pal, R. R. et al., Synthesis of pH-sensitive crosslinked guar gum-g-poly(acrylic acid-co-acrylonitrile) for the delivery of thymoquinone against inflammation, Int. J. Biol. Macromol. 2021 doi:10.1016/j.ijbiomac.2021.05.072.
[20] Mahto, A. & Mishra, S., Design, development and validation of guar gum based pH sensitive drug delivery carrier via graft copolymerization reaction using microwave irradiations, Int. J. Biol. Macromol. 2019 doi:10.1016/j.ijbiomac.2019.07.063.
[21] Ghazanfari, M. R., Kashefi, M., Shams, S. F. & Jaafari, M. R., Perspective of Fe3O4 Nanoparticles Role in Biomedical Applications, Biochem. Res. Int. at https://doi.org/10.1155/2016/7840161 2016.
[22] Ganapathe, L. S., Mohamed, M. A., Yunus, R. M. & Berhanuddin, D. D., Magnetite (Fe3O4) nanoparticles in biomedical application: From synthesis to surface functionalisation, Magnetochemistry at https://doi.org/10.3390/magnetochemistry6040068 2020.
[23] Aliabadi, H. A. M. et al., Magnetic xanthan gum-silk fibroin hydrogel: A nanocomposite for biological and hyperthermia applications, Int. J. Biol. Macromol. 2023 doi:10.1016/j.ijbiomac.2023.127005.
[24] Hassanzadeh-Afruzi, F. et al., Utilizing magnetic xanthan gum nanocatalyst for the synthesis of acridindion derivatives via functionalized macrocycle Thiacalix[4]arene, Sci. Rep. 2023 doi:10.1038/s41598-023-49632-x.
[25] Hassanzadeh-Afruzi, F., Maleki, A. & Zare, E. N., Novel eco-friendly acacia gum-grafted-polyamidoxime@copper ferrite nanocatalyst for synthesis of pyrazolopyridine derivatives, J. Nanostructure Chem. 2023 doi:10.1007/s40097-022-00471-8.
[26] Srinivasan, S. Y., Paknikar, K. M., Bodas, D. & Gajbhiye, V., Applications of cobalt ferrite nanoparticles in biomedical nanotechnology, Nanomedicine at https://doi.org/10.2217/nnm-2017-0379 2018.
[27] Albalah, M. A., Alsabah, Y. A. & Mustafa, D. E., Characteristics of co-precipitation synthesized cobalt nanoferrites and their potential in industrial wastewater treatment, SN Appl. Sci. 2020 doi:10.1007/s42452-020-2586-6.
[28] Thakur, P. et al., Structural, morphological, and magnetic properties of CoFe2O4 nano-ferrites synthesized via Co-precipitation route, Mater. Today Proc. 2023 doi:10.1016/j.matpr.2022.12.233.
[29] Ahmadi, R., Imani, M. & Tadjarodi, A., Microwave Assisted Synthesis of CoFe2O4 Nanoparticles by Utilizing Organic Promoters and Evaluation of Its Properties, 2021. doi:10.3390/ecsoc-24-08351.
[30] Khan, N., Kumar, D. & Kumar, P., Silver nanoparticles embedded guar gum/ gelatin nanocomposite: Green synthesis, characterization and antibacterial activity, Colloids Interface Sci. Commun. 2020 doi:10.1016/j.colcom.2020.100242.
[31] Nguyen, V. C. & Huynh, T. K. N., Reusable nanocomposite of CoFe2O4/chitosan-graft-poly(acrylic acid) for removal of Ni(II) from aqueous solution, Adv. Nat. Sci. Nanosci. Nanotechnol. 2014 doi:10.1088/2043-6262/5/2/025007.
[32] Poursadegh, H., Barzegarzadeh, M. & Amini-Fazl, M. S., Synthesis of Magnetic Graphene Quantum Dot/Chitosan Bionanocomposite Hydrogel Beads for Drug Delivery System, 2023.
[33] Geramipour, M., Kurdtabar, M. & Rezanejade Bardajee, G., Synthesis and Characterization of Iron Magnetic Nanocomposite Hydrogel Based on Modified Sodium Carboxymethyl Cellulose Using Acrylamide and Acrylic Acid and Investigation of Drug Delivery Properties, Iran. J. Polym. Sci. Technol., 29, 265–275 2016.
[34] Rostami, H. & Shiri, L., CoFe2O4@SiO2-PA-CC-guanidine nanoparticles: A novel, efficient, and recyclable catalyst for the synthesis of 3,5-disubstituted-2,6-dicyanoaniline derivatives, Appl. Organomet. Chem. 2020 doi:10.1002/aoc.5599.
[35] Sivagurunathan, P. & Gibin, S. R., Preparation and characterization of nanosized cobalt ferrite particles by co-precipitation method with citrate as chelating agent, J. Mater. Sci. Mater. Electron. 2016 doi:10.1007/s10854-016-4915-5.
[36] Mahto, A. & Mishra, S., Guar Gum Grafted Itaconic Acid: A Solution for Different Waste Water Treatment, J. Polym. Environ. 2021 doi:10.1007/s10924-021-02125-2.
دوره 21، شماره 78
بهار 1404
صفحه 106-94

  • تاریخ دریافت 13 آذر 1403
  • تاریخ بازنگری 18 بهمن 1403
  • تاریخ پذیرش 08 اسفند 1403