دنیای نانو

دنیای نانو

استفاده از نانو ذرات در درمان سرطان کبد

نوع مقاله : مروری

نویسندگان
1 دانشکده علوم زیستی، دانشگاه تربیت مدرس، تهران
2 دانشکده علوم زیستی، دانشگاه شهید بهشتی ، تهران
چکیده
یکی از رایج ترین سرطان موجود در جهان که هر ساله منجر به مرگ میلیون ها انسان می گردد، سرطان کبد می باشد .در میان آنها هپاتو سلولار کارسینوما به عنوان یک معضل سلامت جهانی در نظر گرفته شده است. کاربرد زیستی نانوذرات، یک حوزه در حال توسعه فناوری نانواست که امکانات جدیدی را درتشخیص و درمان سرطان های انسان به وجود می آورد. نانوذرات می توانند از دو روش هدف گیری فعال و غیر فعال در درمان سرطان استفاده کنند. در هدف گیری غیر فعال، به دلیل ساختار غیر طبیعی رگ های خونی در تومور های سرطانی، نانو ذرات از طریق اثر "افزایش نفوذ پذیری و نگهداری" (EPR) به بافت سرطانی نفوذ کرده و در آنجا تجمع می یابند، که این امر باعث کاهش نفوذ دارو به بافت های سالم و کاهش عوارض جانبی می شود. در هدف گیری فعال، نانوذرات به طور اختصاصی با لیگاندهای موجود روی سطح سلول های سرطانی متصل می شوند و به صورت انتخابی به تومور هدایت شده و اثر درمانی مطلوب تری ایجاد می کنند. بنابراین امروزه می توان با استفاده از شیوه های نوین درمان از جمله دارورسانی هدفمند، یک رویکرد جدید در گسترش و بهبود درمان موثر سرطان ارائه داد.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

The use of nanoparticles in the treatment of liver cancer

نویسندگان English

Shahrzad Raeispour 1
Moones Rahmandoust 2
1 1. Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
2 Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran
چکیده English

One of the most common cancer in the world is liver cancer, which kills millions of people every year. Among, hepatocellular carcinoma is considered as a global health problem. The biological application of nanoparticles is a developing field of nanotechnology that creates new possibilities in the diagnosis and treatment of human cancers. Nanoparticles can use both active and passive targeting methods in cancer treatment. In passive targeting, due to the abnormal structure of blood vessels in cancer tumors, nanoparticles penetrate into the cancer tissue and accumulate there through the effect of “Enhanced permeability and retention” (EPR), which reduces the penetration of the drug into healthy tissues and side effects. In active targeting, nanoparticles are specifically bound to ligands on the surface of cancer cells and are selectively directed to the tumor and create a more favorable therapeutic effect. Therefore, today, it is possible to present a new approach for expanding and improving effective the cancer treatment by using new methods of treatment, including targeted drug delivery.

کلیدواژه‌ها English

Hepatocellular carcinoma
EPR
Targeted therapy
Cancer cell
[1] T.F. Greten, Treatment of liver cancer, Liver Biol. Pathobiol. (2020) 782–791. https://doi.org/10.1002/9781119436812.ch61.
[2] S.P. Metkar, G. Fernandes, P.D. Navti, A.N. Nikam, R. Kudarha, N. Dhas, R.N. Seetharam, K.V. Santhosh, B.S.S. Rao, S. Mutalik, Nanoparticle drug delivery systems in hepatocellular carcinoma: A focus on targeting strategies and therapeutic applications, OpenNano. 12 (2023) 100159. https://doi.org/10.1016/j.onano.2023.100159.
[3] M. Yazdani, M. Rahmandoust, H. Kouchakzadeh, Development of various carbon nanoparticles and albumin complexes for potential theranostics applications, J. Drug Deliv. Sci. Technol. 77 (2022) 103901. https://doi.org/10.1016/j.jddst.2022.103901.
[4] R.A. Revia, M. Zhang, Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: Recent advances, Mater. Today. 19 (2016) 157–168. https://doi.org/10.1016/j.mattod.2015.08.022.
[5] S. Raeispour, M. Rahmandoust, H. Kouchakzadeh, A nanocarrier system based on CQDs for efficient mitoxantrone drug delivery, Heliyon. 10 (2024) e31674. https://doi.org/10.1016/j.heliyon.2024.e31674.
[6] S. Lorente, M. Hautefeuille, A. Sanchez-Cedillo, The liver, a functionalized vascular structure, Sci. Rep. 10 (2020) 1–10. https://doi.org/10.1038/s41598-020-73208-8.
[7] A.K. Burroughs, The Hepatic Artery, Portal Venous System and Portal Hypertension: The Hepatic Veins and Liver in Circulatory Failure, Sherlock’s Dis. Liver Biliary Syst. 12th Ed. (2011) 152–209.
[8] N.M. Tunissiolli, M.M.U. Castanhole-Nunes, P.M. Biselli-Chicote, É.C. Pavarino, R.F. da Silva, R. de C.M.A. da Silva, E.M. Goloni-Bertollo, Hepatocellular carcinoma: A comprehensive review of biomarkers, clinical aspects, and therapy, Asian Pacific J. Cancer Prev. 18 (2017) 863–872. https://doi.org/10.22034/APJCP.2017.18.4.863.
[9] I. Lurje, Z. Czigany, J. Bednarsch, C. Roderburg, P. Isfort, U.P. Neumann, G. Lurje, Treatment strategies for hepatocellular carcinoma—A multidisciplinary approach, Int. J. Mol. Sci. 20 (2019) 1–27. https://doi.org/10.3390/ijms20061465.
[10] J. Yu, Z.Z. Wu, T. Li, Y. Xu, Y.C. Zhao, B.L. Zhang, T. Li, Y.C. Zhao, H. Tian, Effectiveness of surgical resection for complicated liver cancer and its influencing factors: A retrospective study, World J. Clin. Cases. 8 (2020) 736–742. https://doi.org/10.12998/wjcc.v8.i4.736.
[11] Y.K. Cho, J.K. Kim, M.Y. Kim, H. Rhim, J.K. Han, Systematic review of randomized trials for hepatocellular carcinoma treated with percutaneous ablation therapies, Hepatology. 49 (2009) 453–459. https://doi.org/10.1002/hep.22648.
[12] M. Ikeda, C. Morizane, M. Ueno, T. Okusaka, H. Ishii, J. Furuse, Chemotherapy for hepatocellular carcinoma: Current status and future perspectives, Jpn. J. Clin. Oncol. 48 (2018) 103–114. https://doi.org/10.1093/jjco/hyx180.
[13] C.P. Chen, Role of radiotherapy in the treatment of hepatocellular carcinoma, J. Clin. Transl. Hepatol. 7 (2019) 183–190. https://doi.org/10.14218/JCTH.2018.00060.
[14] N. Mahmoudi, F. Fatemi, M. Rahmandoust, F. Mirzajani, S.O. Ranaei Siadat, Development of a carbon quantum dot-based sensor for the detection of acetylcholinesterase and the organophosphate pesticide, Heliyon. 9 (2023) e19551. https://doi.org/10.1016/j.heliyon.2023.e19551.
[15] M. Mohammadian, H. Kouchakzadeh, M. Rahmandoust, T. Mohammadian, Targeted albumin nanoparticles for the enhancement of gemcitabine toxicity on cancerous cells, J. Drug Deliv. Sci. Technol. 56 (2020) 101503. https://doi.org/10.1016/j.jddst.2020.101503.
[16] K. Mahmoud, S. Swidan, M. El-Nabarawi, M. Teaima, Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances, J. Nanobiotechnology. 20 (2022) 1–42. https://doi.org/10.1186/s12951-022-01309-9.
[17] L. Qi, Z. Xu, M. Chen, In vitro and in vivo suppression of hepatocellular carcinoma growth by chitosan nanoparticles, Eur. J. Cancer. 43 (2007) 184–193. https://doi.org/10.1016/j.ejca.2006.08.029.
[18] P. Pandey, M. Rahman, P.C. Bhatt, S. Al, B. Paul, A. Hafeez, F.A. Al-Abbasi, M.S. Nadeem, O. Baothman, F. Anwar, V. Kumar, Implication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin, Nanomedicine. 13 (2018) 849–870. https://doi.org/10.2217/nnm-2017-0306.
[19] M. Zhou, Y. Yi, L. Liu, Y. Lin, J. Li, J. Ruan, Z. Zhong, Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinoma, J. Cancer. 10 (2019) 5820–5831. https://doi.org/10.7150/jca.30865.
[20] S. Kianamiri, A. Dinari, M. Sadeghizadeh, M. Rezaei, B. Daraei, N.E.H. Bahsoun, A. Nomani, Mitochondria-Targeted Polyamidoamine Dendrimer-Curcumin for Hepatocellular Cancer Treatment, Mol. Pharm. 17 (2020) 4483–4498. https://doi.org/10.1021/acs.molpharmaceut.0c00566.
[21] Y. Li, S. Wang, Z. Wang, X. Qian, J. Fan, X. Zeng, Y. Sun, P. Song, M. Feng, D. Ju, Cationic poly(amidoamine) dendrimers induced cyto-protective autophagy in hepatocellular carcinoma cells, Nanotechnology. 25 (2014) 455101. https://doi.org/10.1088/0957-4484/25/45/455101.
[22] E. Ahmadian, S.M. Dizaj, E. Rahimpour, A. Hasanzadeh, A. Eftekhari, H. Hosainzadegan, J. Halajzadeh, H. Ahmadian, Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line, Mater. Sci. Eng. C. 93 (2018) 465–471. https://doi.org/10.1016/j.msec.2018.08.027.
[23] A. Jędrzak, B.F. Grześkowiak, K. Golba, E. Coy, K. Synoradzki, S. Jurga, T. Jesionowski, R. Mrówczyński, Magnetite nanoparticles and spheres for chemo- and photothermal therapy of hepatocellular carcinoma in vitro, Int. J. Nanomedicine. 15 (2020) 7923–7936. https://doi.org/10.2147/IJN.S257142.
[24] A. Saei, S. Asfia, H. Kouchakzadeh, M. Rahmandoust, Antibody-modified magnetic nanoparticles as specific high-efficient cell-separation agents, J. Biomed. Mater. Res. - Part B Appl. Biomater. 108 (2020) 2633–2642. https://doi.org/10.1002/jbm.b.34595.
[25] G. Tom, S. Philip, R. Isaac, P.K. Praseetha, S.G. Jiji, V.V. Asha, Preparation of an efficient and safe polymeric-magnetic nanoparticle delivery system for sorafenib in hepatocellular carcinoma, Life Sci. 206 (2018) 10–21. https://. 93 (2018) 465–471. https://doi.org/10.1016/j.msec.2018.08.027.
[23] A. Jędrzak, B.F. Grześkowiak, K. Golba, E. Coy, K. Synoradzki, S. Jurga, T. Jesionowski, R. Mrówczyński, Magnetite nanoparticles and spheres for chemo- and photothermal therapy of hepatocellular carcinoma in vitro, Int. J. Nanomedicine. 15 (2020) 7923–7936. https://doi.org/10.2147/IJN.S257142.
[24] A. Saei, S. Asfia, H. Kouchakzadeh, M. Rahmandoust, Antibody-modified magnetic nanoparticles as specific high-efficient cell-separation agents, J. Biomed. Mater. Res. - Part B Appl. Biomater. 108 (2020) 2633–2642. https://doi.org/10.1002/jbm.b.34595.
[25] G. Tom, S. Philip, R. Isaac, P.K. Praseetha, S.G. Jiji, V.V. Asha, Preparation of an efficient and safe polymeric-magnetic nanoparticle delivery system for sorafenib in hepatocellular carcinoma, Life Sci. 206 (2018) 10–21. https://doi.org/10.1016/j.lfs.2018.04.046.
[26] H. Koulivand, A. Shahbazi, V. Vatanpour, M. Rahmandoost, Novel antifouling and antibacterial polyethersulfone membrane prepared by embedding nitrogen1186/s12951-022-01275-2.
[30] M. Rahmandoust, A. Öchsner, On finite element modeling of single- and multi-walled carbon nanotubes, J. Nanosci. Med. 11 (2021). https://doi.org/10.3390/jpm11080771.
[31] M.M.A. Elsayed, M.E. Mostafa, E. Alaaeldin, H.A.A. Sarhan, M.S. Shaykoon, S. Allam, A.R.H. Ahmed, Design and Optimization of Pectinate-Coated Niosomes for Enhancing the Oral Bioavailability of Methotrexate: In Vitro and In Vivo Evaluation, Pharmaceutics. 14 (2022) 2223. https://doi.org/10.3390/pharmaceutics14102223.
[32] S. Taghizadeh, V. Alimardani, P.L. Roudbali, Y. Ghasemi, E. Kaviani, Gold nanoparticles as a promising candidate for hepatocellular carcinoma therapy: A review, J. Drug Deliv. Sci. Technol. 64 (2021) 102606. https://doi.org/10.1016/j.jddst.2021.102606.
[33] M.F. Attia, N. Anton, J. Wallyn, Z. Omran, T.F. Vandamme, An overview of active and passive targeting strategies to improve the delivery of various drugs to treat hepatocellular carcinoma, J. Control. Release. 226 (2016) 193–204. https://doi.org/10.1016/j.jconrel.2016.02.030.
[34] S. Dhar, F.X. Gu, R. Langer, O.C. Farokhzad, S.J. Lippard, Targeted delivery of cisplatin to prostate cancer cells by dual-targeting Pt(IV) nanoparticles, Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 17356–17361. https://doi.org/10.1073/pnas.0809154105.
[35] Y. Guang, Ligand-modified Nanomaterials for Specific Targeting of Hepatocellular Carcinoma, J. Mod. Nanotechnol. 2 (2022) 1–8. https://doi.org/10.53964/jmn.2022004.
[36] N. Kadeh, S. Sen, A. McClain, J.E. Puskas, J.A. Drazba, G. McLennan, Folic acid conjugated polymeric drug delivery vehicle for targeted cancer detection in hepatocellular carcinoma, J. Biomed. Mater. Res. - Part A. 107 (2019) 2522–2535. https://doi.org/10.1002/jbm.a.36758.
[37] Y. Xu, M. Wang, S. Ning, Z. Yang, L. Zhou, X. Xia, Development of Glycyrrhetinic Acid and Folate Modified Cantharidin Loaded Solid Lipid Nanoparticles for Targeting Hepatocellular Carcinoma, Molecules. 27 (2022) 6786. https://doi.org/10.3390/molecules27206786.
[38] A. Bakrania, G. Zheng, M. Bhat, Nanomedicine in hepatocellular carcinoma: A new frontier in targeted cancer treatment, Pharmaceutics. 14 (2022) 1–25. https://doi.org/10.3390/pharmaceutics14010041.
[39] K. Golla, B. Cherukuvada, F. Ahmed, A.K. Kondapi, Efficacy, Safety and Anticancer Activity of Protein Nanoparticle-Based Delivery of Doxorubicin through Intravenous Administration in Rats, PLoS One. 7 (2012) e51960. https://doi.org/10.1371/journal.pone.0051960.
[40] V. Kumar, M. Rahman, P. Gahtori, F. Al-Abbasi, F. Anwar, H.S. Kim, Current status and future directions of hepatocellular carcinoma-targeted nanoparticles and nanomedicine, Expert Opin. Drug Deliv. 18 (2021) 673–694. https://doi.org/10.1080/17425247.2021.1860939.
[41] F.H. Kong, Q.F. Ye, X.Y. Miao, X. Liu, S.Q. Huang, L. Xiong, Y. Wen, Z.J. Zhang, Current status of sorafenib nanoparticle delivery systems in the treatment of hepatocellular carcinoma, Theranostics. 11 (2021) 5464–5490. https://doi.org/10.7150/thno.54822.
[42] Q. Zhou, L. Zhang, T.H. Yang, H. Wu, Stimuli-responsive polymeric micelles for drug delivery and cancer therapy, Int. J. Nanomedicine. 13 (2018) 2921–2942. https://doi.org/10.2147/IJN.S158696.
[43] P.W. Lee, C.T. Chen, H.W. Sung, M.C. Chen, Paclitaxel-loaded poly(γ-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system against cultured HepG2 cells, Bioconjug. Chem. 17 (2006) 291–299. https://doi.org/10.1021/bc0502107.
[44] C. Zhang, T. An, D. Wang, G. Wan, M. Zhang, H. Wang, S. Zhang, R. Li, X. Yang, Y. Wang, Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma, J. Control. Release. 226 (2016) 193–204. https://doi.org/10.1016/j.jconrel.2016.02.030.
[45] D. Ling, H. Xia, W. Park, M.J. Hackett, C. Song, K. Na, K.M. Hui, T. Hyeon, PH-sensitive nanoformulated triptolide as a targeted therapeutic strategy for hepatocellular carcinoma, ACS Nano. 8 (2014) 8027–8039. https://doi.org/10.1021/nn502074x.
[46] C. Niu, Q. Sun, J. Zhou, D. Cheng, G. Hong, Folate-functionalized polymeric micelles based on biodegradable PEG-PDLLA as a hepatic carcinoma-targeting delivery system, Asian Pacific J. Cancer Prev. 12 (2011) 1995–1999.
[47] G.L. Malarvizhi, A.P. Retnakumari, S. Nair, M. Koyakutty, Transferrin targeted core-shell nanomedicine for combinatorial delivery of doxorubicin and sorafenib against hepatocellular carcinoma, Nanomedicine Nanotechnology, Biol. Med. 10 (2014) 1649–1659. https://doi.org/10.1016/j.nano.2014.05.011.
[48] W. Zhang, F. Peng, T. Zhou, Y. Huang, L. Zhang, P. Ye, M. Lu, G. Yang, Y. Gai, T. Yang, X. Ma, G. Xiang, Targeted delivery of chemically modified anti-miR-221 to hepatocellular carcinoma with negatively charged liposomes, Int. J. Nanomedicine. 10 (2015) 4825–4836. https://doi.org/10.2147/IJN.S79598.
دوره 20، شماره 76
پاییز 1403
صفحه 171-153

  • تاریخ دریافت 03 مهر 1403
  • تاریخ بازنگری 01 اسفند 1403
  • تاریخ پذیرش 09 اسفند 1403