In the past few decades, many studies have been reported to prepare doped metal-organic frameworks and investigate the effect of different metal centers. Metal-organic frameworks are a very suitable option for different applications, including advanced oxidation, adsorption, desulfurization, sensing, drug delivery, and solid-phase extraction, due to their high thermal and chemical stability, high adsorption capacity, and extraordinary surface area. One of the methods that can be used to improve the performance of metal-organic frameworks is to change the metal centers. Here, a brief assessment of the current achievements in the field of the effect of metal centers on the properties and performance of metal-organic frameworks in the above-mentioned various fields is presented. The present study is a review of the effect of these centers on the characteristics of metal-organic frameworks, including changes in topography, peaks of characterization of analyses, and changes in pore size and subsequently the performance of the framework. By adding different metal atoms in the optimal size, the performance of the metal-organic framework is improved, which is discussed here.