The aim of this study is to prepare a slow release formulation of clozapine using glycerol monostearate acid as a solid lipid, and Tween 80 and Triton 100X as surface active agents, as well as chitosan polymer to control drug release.
In the optimized formulation, 50 mg of clozapine, 250 mg of stearic acid, 165 mg of Tween 80 and 70 mg of Triton 100X were used as surfactants and 12.5 ml of a 0.5% chitosan solution with an average molecular weight.
The amount of drug loaded in the presence of chitosan was about 89.9%, which is 3.3% more drug than in the case without the presence of chitosan polymer, and the rate of drug release in the presence of chitosan was 89% in 30 hours, and in the period of -20 5 hours which is the effective time period of the medicine; The corrected percentage in the presence of chitosan was about 30 to 40%; Because the presence of hydroxyl and amine groups of the first type in the chitosan structure allows its chemical modification in terms of controlling its physical properties, and when a hydrophobic component such as glycerol monostearate is combined with the chitosan molecule, it forms self-assembled nanoparticles that are capable of encapsulation Making medicine and delivery It is the target area. The presence of chitosan with appropriate physical and chemical properties allows the nanoparticles to not have an explosive release and release the drug in a more controlled manner.