دنیای نانو

دنیای نانو

مروری بر روش‌های نانوکپسوله کردن تر‌کیبات زیستی و بررسی مکانیزم رهایش آنها

نوع مقاله : مروری

نویسندگان
دانشکده نانوفناوری، پردیس علوم و فناوری های نوین، دانشگاه سمنان، سمنان، ایران
چکیده
امروزه استفاده از مواد زیستی چه به صورت مکمل دارو و چه به صورت غذاهای غنی شده مورد توجه قرار گرفته است. این مواد خواص مختلفی مانند ضدالتهابی، ضدسرطانی، ضد دیابتی، تقویت کننده سیستم ایمنی و ضدمیکروبی را از خود نشان داده اند. اگر چه این ترکیبات از منابع طبیعی منشا می‌گیرند اما در برابر شرایط محیطی از پایداری کمی برخوردار هستند. کپسوله کردن یک روش موثر است که می‌تواند پایداری شیمیایی و بیولوژیکی ترکیبات زیستی را افزایش دهد و همچنین از آن‌ها در برابر واکنش‌های اجتناب ناپذیر محافظت کند. نانوکپسول ها در مقایسه با کپسول‌های میکرو نسبت سطح به حجم بالاتری دارند و برای کاربردهای زیستی درون تنی و برون تنی بسیار مورد توجه هستند. نانوکپسول های پلیمری می توانند از انواع پلیمرهای طبیعی یا مصنوعی تهیه شوند. ترکیبات زیست فعال کپسوله شده باید در مکان و زمان مناسب آزاد شوند. مکانیزم های آزادسازی متعددی برای ترکیبات زیست فعال محبوس شده پیشنهاد شده است که از آن جمله می توان به انتشار ساده، تورم و تجزیه اشاره کرد. رهایش تحت تاثیر شرایط محیطی مانند حلال، دما، فشار، فعل و انفعالات مولکولی، تغییر در اندازه منافذ و از هم پاشیدگی شبکه قرار دارد. در مقاله پیش رو مروری خواهیم داشت بر روش‌های نانوکپسوله ‌کردن‌ ترکیبات زیستی و بررسی مکانیزم رهایش آنها.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

A review of the methods of nanoencapsulation of biological compounds and the investigation of their release mechanism

نویسندگان English

atena ashour
Zohreh Bahrami
Department of Nanotechnology, Faculty of New Sciences and Technologies, Semnan University, Semnan, Iran
چکیده English

Today, the use of biological materials, both in the form of drug supplements and in the form of enriched foods, has been considered. These substances have shown various properties such as anti-inflammatory, anticancer, antidiabetic, immune system booster, and antimicrobial. Although these compounds originate from natural sources, they have little stability against environmental conditions. Encapsulation is an effective method that can increase the chemical and biological stability of biological compounds and also protect them from inevitable reactions. Compared with microcapsules, nanocapsules have a higher surface-to-volume ratio and are of great interest for in vivo and ex vivo biological applications. Polymeric nanocapsules can be prepared from natural or synthetic polymers. Encapsulated bioactive compounds should be released at the right time and place. Several release mechanisms have been proposed for trapped bioactive compounds, including simple diffusion, swelling, and decomposition with diffusion. Release under the influence of environmental conditions such as solvent, temperature, pressure, molecular interactions, changes in pore size, and network disintegration.

کلیدواژه‌ها English

encapsulation
nanocarriers
biological compounds
release
coatings
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دوره 20، شماره 75
تابستان 1403
صفحه 105-114

  • تاریخ دریافت 23 اردیبهشت 1403
  • تاریخ بازنگری 16 مرداد 1403
  • تاریخ پذیرش 29 مرداد 1403