دنیای نانو

دنیای نانو

تشخیص ردپای باقی‌مانده آنتی‌بیوتیک‌ها در محیط‌زیست از طریق فناوری نانوبیوسنسور

نوع مقاله : مروری

نویسندگان
1 دانشیار، فیزیولوژی پزشکی، گروه علوم پایه، دانشگاه فرهنگیان، صندوق پستی 889-14665، تهران، ایران
2 گروه علوم پایه، دانشگاه فرهنگیان، اصفهان، ایران
3 دانشکده آموزش زیست شناسی، دانشگاه فرهنگیان، ایزان، اصفهان
چکیده
استفاده گسترده از آنتی‌بیوتیک‌ها منجر به تجمع بقایای آن‌ها در محیط‌زیست شده است که به دلیل پتانسیل آن‌ها در ارتقاء مقاومت آنتی‌بیوتیکی تهدیدی قابل‌توجه برای سلامت اکولوژیکی و انسان است. تشخیص این بقایا به دلیل غلظت کم و پیچیدگی نمونه‌های محیطی بحث‌برانگیز است. روش‌های سنتی نیز برای تشخیص این باقی‌مانده‌ها اغلب دست‌وپا گیر، وقت‌گیر و فاقد حساسیت هستند. نانوبیوسنسورهایی الکتروشیمیایی، فیزیکوشیمیایی، گاز، مولکولی و متابولیکی راه‌حل امیدوارکننده‌ای را ارائه می‌دهند که حساسیت، انتخابی بودن و قابلیت‌های تشخیص سریع مقادیر کم باقی‌مانده آنتی‌بیوتیک‌ها در محیط را ارائه می‌دهند. مقالات مورد بررسی در پژوهش مروری حاضر مربوط به دوره زمانی 2014 تا 2024 است. این مطالعه کاربرد نوآورانه فناوری نانوبیوسنسورها را به‌عنوان راه‌حلی در تشخیص باقی‌مانده‌های آنتی‌بیوتیک‌ها در محیط بررسی می‌کند و علاوه بر این، مقاله به دنبال مشخص کردن پتانسیل ادغام هوش مصنوعی (AI) با فناوری نانوبیوسنسور برای افزایش قابلیت‌های تشخیص باقی‌مانده آنتی‌بیوتیک‌ها در محیط‌زیست و غلبه بر برخی محدودیت‌ها در این مسیر است.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

Detection of residual traces of antibiotics in the environment through Nanobiosensor technology

نویسندگان English

firoozeh alavian 1
zeinab shohani 2
Aliyeh Arabi 3
1 Associate Professor, Medical Physiology, Department of Basic Sciences, Farhangian University, PO Box 889-14665, Tehran, Iran
2 Department of Biology Education, Farhangian University, Isfahan, Iran
3 Department of Biology Education, Farhangian University, Isfahan, Iran
چکیده English

The widespread use of antibiotics has led to the accumulation of their residues in the environment, which poses a significant threat to ecological and human health due to their potential to promote antibiotic resistance. Detecting these residues is controversial due to their low concentration and the complexity of environmental samples. Traditional methods for detecting these residues are often cumbersome, time-consuming, and lack sensitivity. Nanobiosensors, including electrochemical, physicochemical, gas, molecular, and metabolic types, offer a promising solution that provides sensitivity, selectivity, and the capability to rapidly detect low levels of antibiotic residues in the environment. The articles examined in the current research relate to the period from 2014 to 2024. This study investigates the innovative application of Nanobiosensor technology as a solution for detecting antibiotic residues in the environment. Furthermore, the article seeks to identify the potential of integrating artificial intelligence (AI) with Nanobiosensor technology to enhance the detection capabilities of antibiotic residues in the environment and overcome some limitations in this path.

کلیدواژه‌ها English

Antibiotic
nanobiosensor
selection
sensitivity
environment
artificial intelligence
[1]. Sodhi, K.K., et al., Perspectives on the antibiotic contamination, resistance, metabolomics, and systemic remediation. SN Applied Sciences. 2021;3: 1-25. doi.org/10.1007/s42452-020-04003-3.
[2]. Haghighi poodeh, S., Y. Sefidbakht, and H. Kouchakzadeh. Environmental Pollution Caused by Antibiotics. Science Cultivation. 2019. 09(2): 82-88. doi.20.1001.1.2008935.1398.09.2.4.5.
[3]. Apreja, M., et al., Antibiotic residues in environment: antimicrobial resistance development, ecological risks, and bioremediation. Environmental Science and Pollution Research. 2022: 1-17. doi: 10.1007/s11356-021-17374-w.
[4]. Bilal, M., et al., Antibiotics traces in the aquatic environment: persistence and adverse environmental impact. Current opinion in environmental science & health. 2020; 13: 68-74. doi: 10.1016/j.coesh.2019.11.005.
[5]. Wang, Z., et al., Antibiotics and Antibiotic Resistance Genes in Waters: Pollution, Risks, and Control. Frontiers in Environmental Science. 2022; 10: 967118. doi.org/10.3389/fenvs.2022.967118.
[6]. Toyos-Rodríguez, C., D. Valero-Calvo, and A. de la Escosura-Muñiz, Advances in the screening of antimicrobial compounds using electrochemical biosensors: is there room for nanomaterials? Analytical and Bioanalytical Chemistry. 2023; 415(6): 1107-1121. doi.org/10.1007/s00216-022-04449-x.
[7]. Joshi, A. and K.-H. Kim, Recent advances in nanomaterial-based electrochemical detection of antibiotics: Challenges and future perspectives. Biosensors and Bioelectronics. 2020; 153: 112046. doi.org/10.1016/j.bios.2020.112046.
[8]. Melo, M.C., J.R. Maasch, and C. de la Fuente-Nunez, Accelerating antibiotic discovery through artificial intelligence. Communications biology. 2021; 4(1): 1050. doi.org/10.1038/s42003-021-02586-0.
[9]. Wang, X., et al., A review of graphene-based nanomaterials for removal of antibiotics from aqueous environments. Environmental pollution. 2019; 253: 100-110. 
[10]. Bekele, T. and G. Alamnie, Treatment of antibiotic-resistant bacteria by nanoparticles: current approaches and prospects. Ann Adv Chem, 2022; 6: 001-009. doi.org/10.29328/journal.aac.1001025.
[11]. Guliy, O., et al., Biosensor systems for antibiotic detection. Biophysics. 2021; 66: 555-564. doi.org/10.1134/S0006350921040060.
[12]. Kulkarni, M.B., N.H. Ayachit, and T.M. Aminabhavi. Recent advancements in nanobiosensors: current trends, challenges, applications, and future scope. Biosensors. 2022; 12(10): 892. doi.org/10.3390/bios12100892.
[13]. Lu, N., et al., Recent Advances of Biosensors for Detection of Multiple Antibiotics. Biosensors. 2023; 13(9): 850. doi.org/10.3390/bios13090850.
[14]. Salouti, M. and F. Khadivi Derakhshan, Biosensors and nanobiosensors in environmental applications. Biogenic nanoparticles and their use in agro-ecosystems. 2020: 515-591. doi: 10.1007/978-981-15-2985-6_26.
[15]. Zhou, C., et al., Machine-learning-driven optical immunosensor based on microspheres-encoded signal transduction for the rapid and multiplexed detection of antibiotics in milk. Food Chemistry. 2024. 437: p. 137740. doi: 10.1016/j.foodchem.2023.137740.
[16]. Nano World. 2018; 14(52): 4-12.
[17]. Sezgintürk, M.K. and F. Altay. Biosensors from the first generation to nano-biosensors. International Advanced Researches and Engineering Journal. 2018; 2(2): 200-207.
[18]. Seth, S. and P. Rathinasabapathi. A short review on detection of antibiotics in milk using nanomaterial-based biosensor. Food Analytical Methods. 2022; 15(8): 2181-2192. doi.org/10.1007/s12161-022-02291-6.
[19]. Ye, C., et al., A wearable aptamer nanobiosensor for non-invasive female hormone monitoring. Nature Nanotechnology. 2023: 1-8. doi.org/10.1038/s41565-023-01513-0.
[20]. Yang, S., et al., A label-free fluorescent biosensor based on specific aptamer-templated silver nanoclusters for the detection of tetracycline. Journal of Nanobiotechnology. 2023: 21(1): 22. doi.org/10.1186/s12951-023-01785-7.
[21]. Du, X., et al., A novel nanosensor for detecting tetracycline based on fluorescent palladium nanoclusters. New Journal of Chemistry. 2020; 44(22):9248-9254. doi.org/10.1039/C9NJ06218A.
[22]. Choi, H.K., J.-H. Choi, and J. Yoon, An updated review on electrochemical nanobiosensors for neurotransmitter detection. Biosensors. 2023; 13(9): 892. doi.org/10.3390/bios13090892.
[23]. Hassan, R.Y., Advances in electrochemical nano-biosensors for biomedical and environmental applications: From current work to future perspectives. Sensors. 2022; 22(19):7539. doi.org/10.3390/s22197539.
[24]. Bakirhan, N.K., et al., Current advances in electrochemical biosensors and nanobiosensors. Critical reviews in analytical chemistry. 2022; 52(3): 519-534. doi.org/10.1080/10408347.2020.1809339.
[25]. Dezhakam, E., et al., Electrochemical and optical (bio)sensors for analysis of antibiotic residuals. Food Chemistry. 2023: 138145. doi.org/10.1016/j.foodchem.2023.138145.
[26]. Zhang, Y., et al., Aptamer-modified sensitive nanobiosensors for the specific detection of antibiotics. Journal of Materials Chemistry B. 2020; 8(37): 8607-8613.
[27]. Kulapina, E., et al., Potentiometric Sensors Sensitive to Some Cephalosporin Antibiotics: Properties and Applications. Journal of Analytical Chemistry. 2022; 77(8):963-973. doi.org/10.1134/S1061934822080056.
[28]. Raghu, H., T. Parkunan, and N. Kumar. Application of nanobiosensors for food safety monitoring. Environmental Nanotechnology Volume 4. 2020: 93-129. doi.org/10.1007/978-3-030-26668-4_3.
[29]. Hernandez-Vargas, G., et al., Electrochemical biosensors: A solution to pollution detection with reference to environmental contaminants. Biosensors. 2018; 8(2): 29. doi.org/10.3390/bios8020029.
[30]. Liang, G., et al., Aptamer Sensors for the detection of antibiotic residues—A mini-review. Toxics. 2023; 11(6): 513. doi.org/10.3390/toxics11060513.
[31]. Ulucan-Karnak, F., C.İ. Kuru, and S. Akgöl, Commercial roadmap of nanobiosensor development. Frontiers in Nanotechnology. 2024; 6: 1348308. doi.org/10.3389/fnano.2024.1348308.
[32]. Singh, K., Nanosensors for food safety and environmental monitoring. Nanotechnology for food, agriculture, and environment. 2020: 63-84. doi.org/10.1007/978-3-030-31938-0_4.
[33]. Jaballah, M.B., et al., Development of a sustainable nanosensor using green Cu nanoparticles for simultaneous determination of antibiotics in drinking water. Analytical Methods. 2022; 14(20): 2014-2025. doi: 10.1039/D2AY00419D.
[34]. Li, X., et al., Enhancing the performance of paper-based electrochemical impedance spectroscopy nanobiosensors: An experimental approach. Biosensors and Bioelectronics. 2021; 177: 112672. doi.org/10.1016/j.bios.2020.112672.
[35]. Walther, B.K., et al., Nanobiosensing with graphene and carbon quantum dots: Recent advances. Materials Today. 2020; 39:23-46. doi.org/10.1016/j.mattod.2020.04.008.
[36]. Alabsi, S.S., et al., A review of carbon nanotubes field effect-based biosensors. IEEE Access. 2020. 8: 69509-69521. doi: 10.1109/ACCESS.2020.2987204.
[37]. Gautam, A., et al., Electrical, optical, and mechanical transducer–based nanosensor and nanobiosensor for agricultural applications. Nanotechnology and Nanomaterials in the Agri-Food Industries. 2024: 151-184. doi.org/10.1016/B978-0-323-99682-2.00015-3.
[38]. Touhami, A., Biosensors and nanobiosensors: design and applications. 2014.
[39]. Li, C. and F. Sun. Graphene-assisted sensor for rapid detection of antibiotic resistance in Escherichia coli. Frontiers in Chemistry. 2021; 9: 696906. doi: 10.3389/fchem.2021.696906.
[40]. Kharewal, T., et al., Biosensors for penicillin quantification: a comprehensive review. Biotechnology Letters. 2020; 42: 1829-1846. doi: 10.1007/s10529-020-02970-6.
[41]. Hong, J., et al., A minireview for recent development of nanomaterial-based detection of antibiotics. Biosensors. 2023; 13(3): 327. doi.org/10.3390/bios13030327.
[42]. Mahmoud, A.E.D. and M. Fawzy, Nanosensors and nanobiosensors for monitoring the environmental pollutants. Waste Recycling Technologies for Nanomaterials Manufacturing. 2021: 229-246. doi.org/10.1007/978-3-030-68031-2_9.
[43]. Sun, Y., J. Zhao, and L. Liang, Recent development of antibiotic detection in food and environment: The combination of sensors and nanomaterials. Microchimica Acta. 2021. 188: 1-22. doi.org/10.1007/s00604-020-04671-3.
[44]. Yadav, A. and P.D. Indurkar, Gas sensor applications in water quality monitoring and maintenance. Water Conservation Science and Engineering. 2021; 6(3): 175-190. doi.org/10.1007/s41101-021-00108-x.
[45]. Dincer, C., et al., Disposable sensors in diagnostics, food, and environmental monitoring. Advanced Materials. 2019; 31(30): 1806739. doi: 10.1002/adma.201806739.
[46]. Moradi, S., et al., Nano-biosensors in cellular and molecular biology. Cellular and Molecular Biology. 2018; 64(5): 85-90. doi: 10.14715/cmb/2018.64.5.14.
[47]. Lavrukhina, O., et al., Determination of Residual Amounts of Antibiotics in Environmental Samples and Food Products. Journal of Analytical Chemistry. 2022; 77(11): 1349-1385. doi.org/10.1134/S1061934822110077.
[48]. Srivastava, A.K., A. Dev, and S. Karmakar. Nanosensors and nanobiosensors in food and agriculture. Environmental Chemistry Letters. 2018; 16: 161-182. doi.org/10.1007/s10311-017-0674-7.
[49]. Athira, E., et al., Recent progress in optical nanosensors for antibiotics detection. Applied Nanoscience. 2023; 13(9): 6519-6538. doi: 10.1007/s13204-023-02923-1.
دوره 20، شماره 75
تابستان 1403
صفحه 70-87

  • تاریخ دریافت 28 اردیبهشت 1403
  • تاریخ بازنگری 02 تیر 1403
  • تاریخ پذیرش 26 مرداد 1403