دنیای نانو

دنیای نانو

مروری بر دارورسانی هدفمند نانوداروها توسط میکروسوزن ها؛ معرفی، روش تولید و کاربرد

نوع مقاله : مروری

نویسندگان
1 دانشکده مهندسی و علم مواد، دانشگاه صنعتی خواجه نصیرالدین طوسی، تهران، ایران.
2 دانشکده مهندسی و علم مواد، دانشگاه صنعتی خواجه نصیرالدین طوسی، تهران، ایران. آزمایشگاه مواد پیشرفته و نانوتکنولوژی، دانشگاه صنعتی
چکیده
نگاهی به پژوهش های پیشین نشان می دهد که سامانه های دارورسانی تراپوستی با وجود همه مزایایی که دارند، همچنان برای داروهایی با دوز مصرف روزانه بالا و به صورت هدفمند پاسخگو نبوده و نیاز به طراحی سامانه هایی برای داروهایی با دوز مصرف بهینه تر احساس می شود. در واقع، میزان بارگذاری دارو در این سامانه ها یکی از مشکلاتی است که باید برای رفع آن چاره ای اندیشیده شود. هدف از استفاده از میکروسوزن ها، دارورسانی هدفمند به میزان مشخص به ناحیه مشخص است. در میان میکروسوزن های مختلف، میکروسوزن های پلیمری زیست تخریب پذیر اهمیت ویژه ای دارند و قسمت زیادی از مطالعات جدید را به خود اختصاص داده اند. در مطالعه حاضر سعی بر آن شده است تا در مورد دارورسانی هدفمند نانوداروها و نانوذرات به منظور درمان تومورها و بافت های سرطانی، دارورسانی از طریق پوست، انواع میکروسوزنها و روش های تولید آن ها صحبت شود.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

Review on targeted drug delivery of nanomedicines by microneedles; introduction, production method and application

نویسندگان English

Erfan Bahrami 1
Mehdi Khodaei 2
1 Faculty of Materials Science and Engineering, K. N. Toosi University of Technology, Tehran, Iran.
2 Faculty of Materials Science and Engineering, K.N. Toosi University of Technology, Tehran, Iran
چکیده English

Comprehensive survey of the previous research on targeted medicines shows that transdermal drug delivery systems, despite all the advantages they have, are still not responsive to drugs with high daily dosages and in a targeted manner, and there is a need to design systems for drugs with optimal dosages. In fact, the amount of drug loading in these systems is one of the problems that must be solved. The purpose of using microneedles is to deliver targeted medicine in a specific amount to a specific area. Among different microneedles, biodegradable polymer microneedles are of particular importance and have been the subject of many new studies. In the present study, an attempt has been made to prepare a comprehensive literature review about the targeted drug delivery of nanomedicines and nanoparticles for the treatment of tumors and cancerous tissues by drug delivery through the skin. In addition, the production methods of microneedles have been investigated.

کلیدواژه‌ها English

Microneedle
transdermal system
targeted drug delivery
nanoparticle drug delivery
tumor and cancer
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دوره 19، شماره 72
پاییز 1402
صفحه 71-85

  • تاریخ دریافت 24 تیر 1402
  • تاریخ بازنگری 05 شهریور 1402
  • تاریخ پذیرش 07 آبان 1402