نوع مقاله : مقاله پژوهشی
نویسندگان
1 پژوهشگر پسا دکتری، دانشکده شیمی، دانشگاه صنعتی امیرکبیر ، تهران، صندوق پستی: 4413-15875
2 دانشکده شیمی، دانشگاه صنعتی امیرکبیر ، تهران، صندوق پستی: 4413- 15875
3 پژوهشگاه پلیمر و پتروشیمی، تهران، ایران، صندوق پستی: 14975/112
چکیده
کلیدواژه‌ها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
The utilization of nanoparticles as drug carriers is of utmost importance due to their ability to effectively transport drugs to specific areas of the body at the appropriate time. Incorporating anticancer agents into nanoparticle-based drug delivery systems has emerged as a highly efficient approach for targeting cancer cells. These systems possess the capability to penetrate cells more effectively, enabling the precise combination of drugs within the cells. Moreover, they take advantage of the enhanced permeability and retention (EPR) effect, allowing for better accumulation of drugs at tumor sites. Particle size is a critical factor influencing the efficacy of anticancer nanocarriers. The zeta potential range of -30 to +30 millivolts is particularly favorable for designing nanocarriers, as it ensures their stability in the bloodstream and prolonged circulation. Many studies have indicated that the optimal particle size for targeted drug release falls below 300 or 200 nanometers. This size range facilitates efficient drug diffusion among tissues and enhances permeability. This study, for the first time, focuses on analyzing particle size obtained through dynamic light scattering and evaluating the surface charge potential to enhance the release of anticancer drugs.
کلیدواژه‌ها [English]
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