مروری بر خواص نانوذرات اکسید آهن با پوشش‌های مختلف در کاربردهای زیست‌پزشکی

نوع مقاله : مروری

نویسندگان

1 گروه مهندسی پلیمر، دانشگاه آزاد اسلامی، واحد شیراز، شیراز، ایران

2 گروه مهندسی شیمی و پلیمر، دانشگاه یزد، یزد، ایران

3 گروه مهندسی پلیمر، دانشگاه صنعتی امیرکبیر، تهران، ایران

چکیده

نانوذرات اکسید آهن به دلیل خواص ویژه از جمله رفتار سوپرپارامغناطیس، سمیت کم، زیست‌سازگاری، روش‌های متعدد جهت سنتز و پتانسیل اصلاح سطح آن‌ها با پوشش‌های مختلف، کاربرد گسترده‌ای در حوزه‌های مختلف علوم و مهندسی از جمله زیست‌پزشکی یافته‌اند. با این وجود تشکیل کلوخه، توزیع اندازه پراکنده و نیز اکسیداسیون سریع نانوذرات از جمله چالش‌هایی است که به هنگام استفاده از این مواد وجود دارد. در همین راستا روش‌ها و ترکیبات مختلفی برای سنتز و اصلاح سطحی نانوذرات اکسید آهن به منظور بهبود ویژگی‌ها و افزایش کارایی آن‌ها، معرفی شده است. در این پژوهش براساس تحقیقات و مطالعات پیشین، به مرور مزایا و معایب انواع روش‌های سنتز نانوذرات اکسید آهن، اصلاح سطحی نانوذرات تولید شده به کمک مواد شیمیایی مختلف، کاربردهای نانوذرات اصلاحی و نیز چالش‌های پیشرو به هنگام استفاده پرداخته شده است و پیشنهادات ارائه شده جهت بهبود کارایی این مواد در عرصه زیست پزشکی اعم از درون تن و برون تن، نیز بیان شده است.

کلیدواژه‌ها

عنوان مقاله [English]

A review on the properties of the Iron Oxide nanoparticles coated with different materials used in biomedical applications

نویسندگان [English]

  • amir hossein haghighi 1
  • sara taherinezhad 2
  • Zahra Babaei 3
1 Department of Polymer Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
2 Department of Chemical and Polymer Engineering, Yazd University, Yazd, Iran
3 Department of Polymer Engineering, Amirkabir University of Technology, Tehran, Iran
چکیده [English]

As a consequence of special properties such as superparamagnetic behavior, low toxicity, biocompatibility, numerous ways of synthesis and surface modification capability with diverse materials, nowadays Iron Oxide nanoparticles (IONPs) are widely utilized in a great deal of scientific fields, as well as biomedicine. However, agglomerations formation and broad particle size distribution, beside rapid oxidation are still a challenge of these nano-sized particles. In this regard, several routes of synthesis and many chemicals in order to modify IONPs surface have been proposed so as to enhance their properties and increase their potency. Therefore, in this research based on previous articles and studies, the benefits and the drawbacks of various routes of iron oxide nanoparticles synthesis, surface modification of the produced nanoparticles with different components, the applications of the modified nanoparticles along with the leading challenges are discussed. In addition, suggestions offered by other biomedical researchers and scientists to intensify their performance and their effectiveness in-vitro and in-vivo are stated in the following.

کلیدواژه‌ها [English]

  • Iron Oxide magnetic nanoparticles
  • Coatings
  • Iron Oxide nanoparticles Properties
  • Biomedicine

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دنیای نانو
دوره 18، شماره 66
خرداد 1401
صفحه 54-71

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سابقه مقاله

  • تاریخ دریافت: 18 بهمن 1400
  • تاریخ بازنگری: 27 اسفند 1400
  • تاریخ پذیرش: 07 اردیبهشت 1401

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