شماره 46 - بهار 1396
ICNS7
شماره 47-تابستان 1396
فهرست

نانولوله‎های کربنی بارگذاری شده با دارو‎های ضدسرطانی: یک بستر برای درمان سرطان

نشریه: شماره 42- بهار 1395 - مقاله 3   صفحات :  15 تا 24



کد مقاله:
42-03

مولفین:
میلاد کاظم نژادی
علیرضا سرداریان: دانشگاه شیراز - شیمی
محسن اسماعیل پور


چکیده مقاله:

نانولوله‎های کربنی CNTs به علت ساختار مویینه مانند و سطح بسیار زیادی که دارند، به آن‎ها خصوصیت ظرف به عنوان میزبان برای پرکننده‎های گوناگون و بارگذاری داروها بر روی سطح‎شان می‎دهد و بنابراین به عنوان یک ابزار جدید برای رساندن مولکول‎های درمانی به داخل سلول‎ها پدید آمده‎اند. دارورسانی هدفمند یکی از قابل‎اعتمادترین کاربردهای زیستی نانولوله‎های کربنی می‎باشد. کارهای بسیار گسترده‎ای بر روی تهیه CNTها و عامل‎دار کردن آن‎ها هم بصورت خارجی، یعنی اتصال عناصر عاملی به دیواره خارجی و هم درونی با پر کردن مواد مختلف می‎باشد. مخصوصاً ویژگی ظرف بودن نانولوله‎ها امکان پرکردن CNTها را با مواد مختلف می‎دهد. در مقاله پیش رو مروری می‎شود بر کاربرد نانولوله‎های کربنی به عنوان حامل در درمان سرطان. مطالعات انجام گرفته بر روی عامل¬دار کردن یا پر کردن این نانوذرات با داروهایی مختلف و تأثیر آن در مقایسه با داروهای تنها و بدون حامل مورد بررسی قرار خواهد گرفت.


Article's English abstract:

Thanks to their capillary-like structure and its high aspect ratio of carbon nanotubes CNTs provide a well-characterized container material for hosting miscellaneous fillings and loading of drugs on its surface have emerged as a novel tool for the delivery of therapeutic molecules into cells. Targeted drug delivery is one of the most promising bioapplications of carbon nanotubes. Extensive work has been performed to synthesise CNTs and to functionalise them both exohedrally, i.e. by attaching functional elements to the outer shell, and endohedrally by filling with various materials. The container feature of CNTs allows, in principle, simultaneous filling of CNTs with different materials. In the present article is to review the use of carbon nanotubes as a carrier in the treatment of cancer. Studies on functionalization or filling of these nanoparticles with various drugs and their impact on the drugs compared to non-carriers will be examined.


کلید واژگان:
پاکلیتاکسل، دوگزوروبیسین، سرطان، سیستم‎های دارورسانی، نانولوله‎های کربنی.

English Keywords:
Paclitaxel, Doxorubicin, Cancer, Drug delivery systems, Carbon nanotubes.

منابع:
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English References:
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